Digestive Diseases Centers

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Ramnik Xavier, M.D., Ph.D.
Program Director, Center for Inflammatory Bowel Disease
Massachusetts General Hospital/Harvard Medical School
Research Interests: Research Interests: Systems approaches to innate and adaptive immunity


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Eugene B. Chang, M.D.
Martin Boyer Professor of Medicine
DDRCC Director and Host-Microbe Core Director
University of Chicago
Research Interests: Host-microbial interactions, particularly as they relate to health, digestive diseases and other immune- and metabolic-related disorders



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Jorge A. Bezerra, M.D.
Director, Cincinnati Digestive Health Center
Cincinnati Children's Hospital
Research Interests: Liver development, regeneration, and repair; molecular basis of biliary atresia; genetic basis of intrahepatic cholestasis


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Enrique Rozengurt, D.V.M., Ph.D.
Director
CURE: Digestive Diseases Research Centers
Research Interests: Signal transduction pathways in the action of gastrointestinal peptides, bioactive lipids and growth factors in normal and cancerous cells of the digestive system


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David A. Shafritz, M.D.
Director, Marion Bessin Liver Research Center
Albert Einstein College of Medicine of Yeshiva University, New York
Research Interests: Liver gene regulation, growth control, and liver repopulation


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Hans-Christian Reinecker, M.D.
Director,Genetics, Genomics and Molecular Biology Core
Massachusetts General Hospital/Harvard Medical School
Research Interests: Mucosal immunity, innate immune defenses, dendritic cell function and intestinal microbiome


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Charles A Parkos, M.D., Ph.D.
Director, Division of Digestive Diseases
Emory University School of Medicine
Research Interests: Pathobiology of leukocyte interactions with mucosal epithelia


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Wayne I. Lencer, M.D.
Co-Director HDDC, Professor of Pediatrics,
Childrens Hospital Boston, Harvard Medical School
Research Interests: mechanisms for how intestinal epithelial cells interact with theluminal and sub-epithelial microenvironment, and the cell biology of bacterial pathogenesis and mucosal host defense


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Mark Donowitz, M.D.
Director,
Hopkins Digestive Diseases Basic and Translational Research Core Center
Research Interests: All diseases of the liver; general gastroenterology

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Nicholas F. LaRusso, M.D.
Director, Center for Cell Signaling in Gastroenterology
Mayo Clinic
Research Interests: Hepatic epithelial cell function and dysfunction


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Chung Owyang, M.D.
Director, Digestive Health Center
Director, In Vivo Studies Core
University of Michigan
Research Interests: Neurohormonal control of digestive functions including pancreatic endocrine and exocrine secretion, GI motility, and eating behavior



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Anil K. Rustgi, M.D.
Director, Center for Molecular Studies in Digestive and Liver Diseases
University of Pennsylvania, School of Medicine
Research Interests: Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI)


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Harry B Greenberg, M.D.
Director, Digestive Disease Center
Stanford School of Medicine
Research Interests: Pathogenic viruses that infect the GI tract and liver


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Mary K. Estes, Ph.D.
Director, Texas Medical Center Digestive Diseases Center
Baylor College of Medicine
Research Interests: Viral diarrhea, Norwalk virus, rotavirus and mucosal immunity, translational biology and molecular medicine


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Lars Eckmann, M.D.
Director, Digestive Disease Research Development Center
University of California, San Diego
Research Interests: Infections of the intestinal tract with microbial pathogens and inflammatory bowel disease


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Phillip D. Smith, M.D.
Director, Mucosal HIV and Immunobiology Center
University of Alabama
Research Interests: Mucosal immune responses to enteric pathogens or pathogens acquired via mucosal surfaces, including HIV-1, H. pylori and cytomegalovirus (CMV)


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Jacquelyn J. Maher, M.D.
Director, UCSF Liver Center
Research Interests: Clinically relevant diseases such as drug-induced liver injury and nonalcoholic steatohepatitis (NASH)

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Robert Sandler, M.D., M.P.H.
Director, Center for Gastrointestinal Biology and Disease
UNC
Research Interests: Colon cancer etiology, screening and prevention


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Neil Kaplowitz, M.D.
Director, USC Liver Transplant program and Center for Liver Disease
USC, Los Angeles
Research Interests: Drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, ER stress, mitochondrial biogenesis


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Richard M. Peek, Jr., M.D.
Director, Digestive Disease Research Center
Vanderbilt University
Research Interests: Pathogenesis of Helicobacter pylori infection and gastric cancer


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Nicholas Davidson, M.D.
Director, Division of Gastroenterology
Washington University
Research Interests: Complex lipid trafficking from cells of the small intestine and liver


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Michael H Nathanson, M.D., Ph.D.
Director, Yale Liver Center
Research Interests: Mechanisms and effects of calcium signals in polarized epithelia; effect of spatial organization of calcium signals on organ function regulation; factors that organize Ca2+ waves in hepatocytes; organization and effects of Ca2+ waves in cholangiocytes; mechanisms and effects of Ca2+ signals in the nucleus